Fenbendazole is a broad-spectrum benzimidazole antiparasitic drug with established safety and efficacy in numerous animal species. It exerts its anthelmintic effects by binding to b-tubulin microtubule subunits and blocking their polymerization. It also displays cytotoxic properties similar to those of cytotoxic anticancer drugs.
This suggests that fenbendazole may be useful for treating human cancers, especially those with a p53 mutation. A p53 mutation allows cancer cells to grow and proliferate unchecked by the normal cell-protecting mechanisms that keep other types of cells under control. By destroying the microtubules that sustain cancer cells, fenbendazole prevents them from dividing and spreading. It can also boost the production of p53, which keeps mutant cancer cells in check.
To test the effectiveness of fenbendazole for cancer, researchers used mice with xenografts (cancer cells implanted into the body). The mice that received a pre-treatment with fenbendazole had no tumor growth, while the control mice with a fenbendazole-free diet developed large tumors. Researchers theorized that the fenbendazole may have depleted the nutrients needed for the cancer cells to survive and grow.
A team at City of Hope conducted a clinical trial with human cancer patients to determine whether fenbendazole could be combined with other natural products to enhance its anti-tumor effects. Their study showed that combining fenbendazole with quercetin and vitamin E dramatically improved its ability to shrink tumors and extend survival in mice with metastatic ovarian cancer.
In addition, they found that the combination of fenbendazole with rapamycin, which is known to block phosphorylation of cyclin B1, significantly increased its anti-tumor effect. They also discovered that combining the drug with a fatty acid called rapeseed oil reduced its toxicity and increased its bioavailability.
They conclude that the fatty acid may help to protect against some of the gastrointestinal side effects associated with the medication. They also discovered that fenbendazole and the rapeseed oil combination caused more complete tumor regression than free fenbendazole or rapamycin alone.
When it comes to purchasing fenbendazole, most people opt for brands like Panacur C, Safeguard, and Happy Healing. These brands are regularly chosen because they follow a regulated process and have consistently demonstrated the quality of their product through third-party lab results. Additionally, they offer worldwide shipping, making them a viable option for patients from all over the world.
While fenbendazole is generally considered safe, it is not recommended for pregnant or breastfeeding women and children. People with weakened immune systems or liver disease should avoid it as well. However, it is generally well tolerated by most adults and does not interact with any common medications. It can be taken orally or topically. It is usually taken as a powder, but it can also be mixed with food or water. It is best to take it with a meal for maximum absorption. It is also important to drink plenty of water. This will help to flush out any toxins that are accumulated from the treatment. fenbendazole cancer treatment